Fig. 1. Histone deacetylase (HDAC) activity in renal cortex corticis tubule cells (A, C, E, G) and cardiomyocytes (B, D, F, H) from rats aged 90 days was downregulated in malnourished rats, and restored by Losartan and Valproate. Panels A and B show HDAC activity in homogenates from renal cortex corticis and left ventricle cardiomyocytes, respectively. Empty bars: normonourished rats (C); black bars: malnourished (M) rats. In the rest of the panels, vertical dashed lines separate normonourished and malnourished groups. The left sections of all the panels correspond to normonourished rats; the right sections correspond to malnourished rats. Abbreviations of the groups are indicated on the abscissae, according to the nutritional status and the timeline of pharmacological interventions with Losartan, Valproate or combination of both drugs, as described in the text and Supplementary Table 1. The data are mean ± SEM (n = 5-6). Differences were assessed by Student's t-test. The p values are indicated within the panels.